| Magnetic Hyperthermia properties of Biocompatible Iron Oxide Nanoparticles Coated with Oleic acid and Polyethylene glycol with different concentrations |
| Paper ID : 1545-UFGNSM-FULL |
| Authors: |
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Reza Asadi1, Saeid Ebrahimisadr2, Iraj Ahadzadeh *3, Shiva Rashidikia4 1N.33, Tavanir, Abbasi Street, Tabriz, Iran 2Iran, Tabriz,azadi Ave, tabrizno alley, in front of rasoul allah masque, No 24 3Tabriz, 29 bahman blvd, university of tabriz . 5166616471 4Department of Physics, University of Tabriz |
| Abstract: |
| Nano sized magnetic iron oxide nanoparticles such as magnetite coated with hydrophilic water soluble polymers have received increasing attention due to their wide spreading biomedical applications. One of the important applications of Fe3O4 magnetic nanoparticles is their usage in drug delivery. Capping agent such as Oleic acid (OA) and Polyethylene glycol (PEG) are widely used in magnetite nanoparticle synthesis because they can form a dense protective mono layer, which is strongly bonded to the surface of nanoparticles. In the present investigation, Fe3O4 nanoparticles were synthesized via alkaline precipitation method and were surface modified with OA and PEG under air atmosphere at 80 °C for 30 minutes. This study demonstrates the effect of capping of OA and PEG on the surface behavior of Fe3O4 MNPs. The amount of our capping agents in the sample is determined by Fourier transform infrared spectroscopy. XRD studies confirmed coating of Fe3O4 MNPs with OA and PEG. XRD pattern proved inverse spinel structure of the particles. SEM images showed that the particles are mono dispersed, spherical-shaped having diameter of approximately 21 nm in case of bare, 18 nm and 15 nm for PEG and OA coated particles respectively. Particles are dispersed in water with a concentration ranging from 2, 5 and 10 mg.ml-1. The prepared OA and PEG coated Fe3O4 nanoparticles exhibit superparamagnetic behavior and high saturation magnetization. Their heating induction ability was investigated to anticipate their possible use in hyperthermia therapy of cancer. Achieved data indicate that the Specific Absorption Rates (SAR) for coated nanoparticles are greater than the bare ones. |
| Keywords: |
| iron oxide - Oleic acid - PEG - precipitation - hyperthermia |
| Status : Paper Accepted (Poster Presentation) |
