| Effect of alternating magnetic field and size on Magnetic Hyperthermia properties of Fe3O4 nanoparticles synthesized by solvothermal method |
| Paper ID : 1537-UFGNSM-FULL |
| Authors: |
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Saeid Ebrahimisadr1, Reza Asadi2, Iraj Ahadzadeh *3, Tanin Kazemzadeh4 1Iran, Tabriz,azadi Ave, tabrizno alley, in front of rasoul allah masque, No 24 2N.33, Tavanir, Abbasi Street, Tabriz, Iran 3Tabriz, 29 bahman blvd, university of tabriz . 5166616471 4Department of Physics - University of Tabriz |
| Abstract: |
| Magnetic hyperthermia using superparamagnetic Iron Oxide nanoparticles has recently drawn huge attraction due to its clinical promises. Rate of heat generated by Iron oxide nanoparticles in a ferrofluid is affected by their size and the exerted alternating magnetic field. In the present work, we have investigated the effect of AC magnetic field and size in Magnetic Hyperthermia (MH) in ferrofluid, consisting of Magnetic Fe3O4 nanoparticles (MNPs). Fe3O4 nanoparticles were synthesized by solvothermal method which is the best method for the precise control over the size, shape distribution and crystallinity of Iron oxide nanoparticles. The MNPs were characterized by Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), Fourier Transmission Infrared (FT-IR) spectra and Energy-Dispersive X-ray (EDX). XRD pattern indicated that MNPs are pure Fe3O4 with crystalline structure. The FT-IR spectroscopy confirmed formation of metal-oxygen bonds in the octahedral and tetrahedral spinel sub-lattice which further confirmed crystalline structure of the sample. SEM image showed that the mean diameter of MNPs are approximately 5, 12 and 20 nm, suggesting single-domain and superparamagnetic behavior of MNPs. Three suspensions of different size MNPs with concentration of 10% in distilled water was prepared. We applied alternating magnetic field with frequency of 100 kHz with the magnetic field between 10-70 mT for 10 minutes to each sample. Then the temperature rise (ΔT) of the size dependent suspensions in different AC magnetic field was studied. Also the Specific Absorption Rate (SAR) as a prominent parameter in magnetic hyperthermia was obtained from Box-Lucas 1 and linear fitting. Based on the findings of the study and by considering the comparison of the SAR of the each sample in different AC magnetic fields, it is suggested that the nanoparticles with diameter of 20 nm are most suitable choice for biomedical purposes |
| Keywords: |
| Fe3O4 - Hyperthermia - nanoparticle - superparamagnetic - solvothermal |
| Status : Paper Accepted (Poster Presentation) |
