| Diemeter Size Optimization of PLGA Nanocarriers Based on 5-Fluorouracil Generating by Microfluidic Method |
| Paper ID : 1238-UFGNSM-FULL |
| Authors: |
|
Mahtab Ghasemi Toudeshkchoie1, Masoud Soleimani2, payam zahedi *3 18th Floor-2nd Entrance-11th Building-Omid Complex-Babaee Highway-Sadr Highway-Tehran-Iran 2Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran 3University of Tehran, Tehran, Iran |
| Abstract: |
| Nowadays, the main challenge of researchers in the field of cancer therapy is minimizing the chemotherapy side effects of drugs on uninvolved tissues. One of the effective approaches to enhance and modify the drugs performance is utilizing some methods which generate drug-loaded particles along with controlled drug release. Microfluidic systems due to their low material consuming because of their miniaturized dimensions, production time decrease, and controlled properties in biochemical environments have been investigated. 5-fluorouracil (5-FU) is an anticancer medicine which specialized for treatment of colorectal malign diseases. In this project for increasing the drug efficiency, it was encapsulated into the poly (lactic-co-glycolic acid) (PLGA) as a polymeric carrier via microfluidic method that causes the generation of monodispersed and fine particles. The effective parameters influencing on diameter size of mentioned drug carriers are including type of pattern, flow rates of micro-syringe pumps, concentration of polymer and drug solutions, and concentration of surfactant [poly (vinyl alcohol)] as a stabilizer of generated nanoparticles. Based on hydrodynamic flow focusing phenomenon to provide the drug-loaded nanoparticles with diameter size of 101±19 nm, the optimum conditions in order of mentioned above were as follows: fork shape, 5 mL/h for side channels and 1.5 mL/h for middle channel in fork section, 0.1 %(w/v), 0.015 %(w/v) and 0.15 %(w/v). It has been found that these optimized nanocarriers can be a proper candidate for colon cancer treatment. |
| Keywords: |
| Microfluidic method, Nanocarrier, 5-Fu, PLGA, Flow focusing, Optimization |
| Status : Paper Accepted (Oral Presentation) |
