| 5-Fluorouracil-Loaded Nanofibrous Mats Based on Chitosan/Poly (vinyl alcohol) Blends: A Case Study on Morphology and Drug Release |
| Paper ID : 1221-UFGNSM-FULL |
| Authors: |
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Rashin Eshghiesfahani1, payam zahedi *2, Reza Zarghami3 1No.24 Razi Alley, Niazzadeh St, Fallahi St. Valiasr St. 2University of Tehran, Tehran, Iran 3School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran |
| Abstract: |
| Cancer is a large and mysterious class of disease in which cells proliferate in an uncontrollable and disorderly manner, attack to other tissues and destroy them. Currently, employing nanotechnology is an efficient tool for cancer therapy. This work was aimed to prepare nanofibrous mats based on chitosan (CS)/poly (vinyl alcohol) (PVA) blends containing 5-fluorouracil (5-FU) using electrospinning. The morphology and the drug release were characterized by means of scanning electron microscopy (SEM) and ultraviolet-visible (UV-vis) spectrophotometry, respectively. Moreover, the drug-polymer interactions were studied using Fourier transform infrared (FTIR) spectroscopy. In this line, three CS/PVA blends nanofibrous samples were produced with different ratios of 70/30, 50/50 and 30/70. The SEM images showed that the CS/PVA (70/30) nanofibrous sample has the smallest average diameter compared to the others with the value of 91±35 nm. Towards 5-Fu release in phosphate buffer solution (PBS, pH 7.4), after crosslinking all the samples with glutaraldehyde vapor, the results revealed that the sample based on CS/PVA (70/30) blend nanofibers had a sustained control release of the drug without plateau regime until 24 h. The FTIR outcomes proved that there were neither physical nor chemical interactions between the drug and polymers during the electrospinning process. Finally, the results conducted us, the (70/30) CS/PVA blend nanofibrous sample can be a promising candidate used for potentially cancer therapy. |
| Keywords: |
| Nanofibers, Chitosan, Poly (vinyl alcohol), 5-Fluorouracil, Drug release |
| Status : Paper Accepted (Poster Presentation) |
