| Nanographene Oxide and Vitamin D Delivery |
| Paper ID : 1172-UFGNSM-FULL |
| Authors: |
|
Reza Mahdavi *1, Mehran Solati-Hashjin2, Meisam Omidi3, Arash Khojasteh4 1Number 171, Mousavian alley, Masoudieh town, Afsarieh, Tehran, Iran 2Faculty of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Ave, Tehran, Iran. 3Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Taleghani University Hospital, Tehran, Iran. 4Department of Oral and Maxillofacial Surgery, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Taleghani University Hospital, Tehran, Iran. |
| Abstract: |
| One of the most interesting and recent insights into biomimetic scaffold nanobiomaterial is smart scaffolding with targeted drug delivery ability. In recent decades, the use of graphene-based materials, such as nanographene oxide (nGO), as a drug carrier with amphiphilic properties, attracted considerable attention of scientists and researchers in this field. In addition, one of the important global problems is increased vitamin D deficiency, particularly in pregnant and postmenopausal women. Therefore, in this work, by considering hydrophobic properties of vitamin D, we attempted to examine its loading and release both in the presence of surfactant and surfactant-free nGO-aqueous solution. At first, nGO powder was synthesized by modified Hummer’s method. After the preparation of vitamin D and Tween-80 solution, they were added to 0.1 wt% nGO aqueous solution. Simultaneously, the next vitamin D and nGO aqueous solution was prepared in a surfactant-free mode. In order to evaluate the loading content, both solutions were centrifuged, and their supernatant was analyzed by UV-Visible spectroscopy. Additionally, FTIR spectroscopy was employed to determine the Tween-80 effects on vitamin D and nGO. The results have shown that vitamin D loading in surfactant-free solution was approximately 0% while in the presence of Tween-80 it was approximately 30-40%. Therefore, the combination of vitamin D, Tween-80, and nGO can be a suitable candidate for carrying hydrophobic drugs in smart scaffolding, especially in bone tissue engineering. |
| Keywords: |
| Nanographene Oxide, Vitamin D, Tween-80, Drug delivery |
| Status : Paper Accepted (Poster Presentation) |
