| Drug Delivery of Modified Polyethylene terephthalate (PET) Fabric Using β-CD/PAMAM/Ag Nanocomposites |
| Paper ID : 1132-UFGNSM-FULL |
| Authors: |
|
Amir Hossein Keshavarz *1, Majid Montazer2, Neda Soleimani3 1Unit 11, No.1 , Sadat alley, Behnud St. , Ghasr-dasht St. Azarbayjan Ave.,Tehran city, Tehran province, Iran 2Faculty of Textile engineering department of Amir Kabir University of technology (AUT) 3Faculty of Biological Sciences at Microbiology department of Shahid Beheshti University (SBU) |
| Abstract: |
| Nowadays, drug delivery by technical textiles such as abdominal meshes is used in researches for wound dressing and implants as the most useful materials. β-cyclodextrin (β-CD) has hydrophobic cavity and capable to carry drugs and release them slowly. In this paper, poly ethylene terephthalate (PET) fabric is modified at high temperature (HT) with polyamidoamine PAMAM/β-CD/silver (Ag) nanocomposites to produce an antibiotic drug (Ciprofloxacin) delivery and release property. PAMAM improved the hydrophilic properties of the polyester fabric through aminolysis. The aminolised PET is capable to link with β-CD/Ag composites having the hydrophobic cavities for inclusion of hydrophobic drugs. The absorption and release behavior of the treated fabrics were investigated in aqueous and phosphate buffer solutions respectively by UV-Visible of ciprofloxacin. The drug absorption increased to 17.4 % of initial drug after 24 h. the encapsulated drug molecules slowly released in buffer solution after 90 min. The release test indicated that 45 % of the absorbed drug released from β-CD. The synthesized nano composites are detected by FESEM on modified fabric and EDX and Mapping test showed the percentages and distribution of carbon, nitrogen and oxygen elements on the fabric surface. The antibacterial properties of the fabrics were studied against E. coli and S. aureus indicated 99.99 and 95 % bacterial reduction respectively due to synthesized Ag in the β-CD-Ag nanocomposites. |
| Keywords: |
| polyethylene terephthalate, Betacyclodextrin, polyamidoamine, silver, Ciprofloxacin, drug delivery |
| Status : Paper Accepted (Poster Presentation) |
