| Fabrication of novel nanohybrid piezoelectric scaffold for nerve tissue engineering |
| Paper ID : 1056-UFGNSM-FULL |
| Authors: |
|
nadia abzan * 8415683111 |
| Abstract: |
| Peripheral nerve injury is a serious health concern for society that results in partial or complete interruption of normal physiology of the nerve. Artificial nerve grafts with appropriate physiological properties such as mechanical strength, physical guidance and electrical signals have been created for peripheral nerve regeneration. Piezoelectricity is one of the most important properties for nerve tissue engineering which could promote the regrowth and regeneration of nerve tissue. The aim of this study was to develop nanohybrid piezoelectric scaffold based on poly(vinylidene fluoride) (PVDF)-Graphene using nonsolvent-induced phase separation (NIPS) and thermally induced phase separation approach for nerve tissue engineering. Moreover, effects of different contents of Gr on the physical and mechanical properties of the scaffolds were investigated. Scaffolds were quenched in the coagulation bath with DMF:water ratio of 6:4 at 20ᵒC for 6 h, which resulted in the formation of biocontinous structure. Scanning electron microscope (SEM), X-ray diffraction (XRD) and Differential scanning calorimetry (DSC) were adopted to characterize scaffold properties. Results revealed that incorporation of 2 wt.% Graphene resulted in improvement of strength, elastic modulus and elongation of pristine PVDF scaffold. The average pore size of the scaffolds decreased with increasing the Gr contents up to 5wt%. XRD pattern confirmed the existence of β phase with piezoelectric properties in the scaffolds. Moreover, Based on our results, PVDF-Graphene scaffold could be a promising scaffold for nerve tissue engineering application. |
| Keywords: |
| Graphene; nervous system; phase separation; piezoelectric |
| Status : Paper Accepted (Poster Presentation) |
