| Fabrication Hemocompatible (PCL-1α)-heparin Nanocomposite Fibrous membrane for bone tissue Regeneration |
| Paper ID : 1046-UFGNSM-FULL (R1) |
| Authors: |
|
Morteza Alehosseini *1, Nasim Golafshan2, Tahmineh Ahmadi3, Mahshid Kharaziha4 18318655663 2No. 205, Mehregan Alley, East Mehrdar Street, Tohid Street, 3Department of Materials Engineering, Shahreza Branch, Islamic Azad university, 86137, Isfahan, Iran. 4Biomaterials Research group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84154, Iran |
| Abstract: |
| Despite of the wide application of polycaprolactone (PCL) for bone tissue engineering application, its poor cellular interactions have resulted in the development of various strategies for surface modification. A membrane technique used to generate new bone around implants, which is one of the most promising augmentation techniques to cover the bone defect to encourage new bone ingrowth while preventing the ingrowth of fibrous tissue into the grafted site. The aim of this study is to improve not only the bioactivity of Polycaprolactone fibrous membrane but also enhance the hemostatic properties by Heparin. At optimized concentration of ɑ-TCP incorporated membrane (1 wt.%), various concentration of heparin nanodrug incorporated in PCL-1ɑ fibrous membrane. Finally, structural, chemical, and hemostatic properties of membranes were evaluated. Results demonstrated successfully development of tough and flexible fibrous membrane enhanced mechanical and hemostatic characterizations and fibrous structure of the (PCL-1α)-hep membrane indicates the potential effectiveness of this novel nanocomposite in bone tissue application. |
| Keywords: |
| Nanocomposite fibrous membrane, Heparin nanodrug, PCL, GBR application |
| Status : Paper Accepted (Poster Presentation) |
